Hubungan Kadar Interleukin-6 (IL-6) Dengan Neutrophil Lymphocyte Ratio (NLR) Pada Pasien COVID- 19
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Latar belakang: COVID-19 menjadi masalah kesehatan di dunia. Penanda inflamasi yang dapat digunakan sebagai predictor prognosis COVID-19 salah satunya Interlukin-6 (IL-6) dan Neutrofil Lymphocyte Ratio (NLR). Tujuan penelitian: mengetahui hubungan kadar IL-6 dengan NLR pada pasien COVID-19. Metode: Penelitian kuantitatif dengan desain cross sectional. Data yang dikumpulkan dari rekam medik pasien COVID-19 di RS Kanker Dharmais periode Januari-Juli 2021. Jumlah sampel sebanyak 70 pasien yang memenuhi kriteria inklusi dan eksklusi. Analisa data dilakukan secara univariat dan bivariat dengan korelasi spearman. Hasil: Dari 70 pasien COVID-19 sebagian besar berusia dalam kategori lansia akhir (56-65 Tahun) 17 (24,3%) dan jenis kelamin sebagian besar laki-laki yaitu 42 (60%). Rata-rata kadar IL-6 43,34 pg/ml dan rata-rata NLR 12,73. Ada korelasi antara kadar IL-6 dengan NLR pada pasien COVID-19 (P Value=0,000; nilai r 0.563). Kesimpulan:Â Adanya korelasi positif IL-6 dengan NLR. IL-6 adalah salah satu biomarker yang digunakan untuk memprediksi prognosis COVID-19 karena pemeriksaannya yg kompleks, tidak dapat memprosesnya di lab yg sederhana. Sebagai gantinya, kami menyimpulkan pemeriksaan NLR dapat menjadi biomarker alternatif.
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Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020 May;109:102433.
Sukmana M, Yuniarti FA. The Pathogenesis Characteristics and Symptom of Covid-19 in the Context of Establishing a Nursing Diagnosis. J Kesehat Pasak Bumi Kalimantan. 2020;3(1):21.
Sutedja E. Peran Sitokin Dalam Patofisiologi Berbagai Penyakit Berbasis Imun, Dan Kemungkinannya Menjadi Kunci Pengendalian Respons Imun. PERDOSKI [Internet]. 2020;47(4).
Adela N, Zulkarnain M, Flora R. Hubungan Fungsi Paru dengan Kadar Interleukin-6 (Il-6) Pada Penduduk Yang Berada Di Sekitar Pabrik Karet Gandus Dan Tempat Pembuangan Akhir (Tpa) Sampah Sukawinatan Palembang. Biomed J Indones J Biomedik Fak Kedokt Univ Sriwij. 2019;5(1):43–51.
Nugroho P. Perubahan Konsentrasi Interleukin-6, C-Reactive Protein dan Soluble Vascular Cell Adhesion Molecule-1 Pada Pasien Hemodialisis dengan Dialiser Proses Ulang. J Penyakit Dalam [Internet]. 2016;3(3).
Liu S, Wang X, She F, Zhang W, Liu H, Zhao X. Effects of Neutrophil-to-Lymphocyte Ratio Combined With Interleukin-6 in Predicting 28-Day Mortality in Patients With Sepsis. Front Immunol. 2021;12 (March): 1–9.
Wulandari T. Rasio Neutrofil Limfosit Sebagai Prediktor Tingkat Keparahan Stroke Iskemik. J Ilm Kesehat Sandi Husada [Internet]. 2019;10(2 SE-Articles):217–21. Available from: https://akper-sandikarsa.e-journal.id/JIKSH/ article/view/153
Amanda DA. Rasio Neutrofil-Limfosit pada Covid-19; Sebuah tinjauan literatur. Wellness Heal Mag. 2020;2(2):219–23.
Kangdra WY. Karakteristik Klinis Dan Faktor Komorbid Pada Pasien Dalam Pengawasan (PDP) Coronavirus Disease 2019 (COVID-19) di RS Mitra Medika Amplas [Internet]. Medan : Universitas Sumatera Utara; 2021. Available from: http://repositori.usu.ac.id/ handle/123456789/30672
Sayah W, Berkane I, Guermache I, Sabri M, Lakhal FZ, Yasmine Rahali S, et al. Interleukin-6, procalcitonin and neutrophil-to-lymphocyte ratio: Potential immune-inflammatory parameters to identify severe and fatal forms of COVID-19. Cytokine. 2021;141(April).
Begley S. Which Groups Are Most at Risk From the Coronavirus. Am J [Internet]. 2020; Available from: https://doi.org/10.1101/2020.02.17.20024166 V3.FULL.PDF
Qun S, Wang Y, Chen J, Huang X, Guo H, Lu Z, et al. Neutrophil-to-Lymphocyte Ratios Are Closely Associated With the Severity and Course of Non-mild COVID-19. Front Immunol. 2020;11 (September):1–11.
Rajanna AH, Krishnegowda R, Govindaiah RM. To Correlate Serum Ferritin Levels with Clinical Outcome in Covid-19 Patients. Asian J Med Sci. 2021;12(5):25–9.
Yang B, Chang X, Huang J, Pan W, Si Z, Zhang C, et al. The role of IL-6/lymphocyte ratio in the peripheral blood of severe patients with COVID-19. Int Immunopharmacol [Internet]. 2021;97:107569. Available from: https://doi.org/ 10.1016/j.intimp.2021.107569
Kemenkes RI. COVID-19 INDONESIA Per 16 Mei 2021. INFEKSI EMERGING Media Inf Resmi Terkini Penyakit Infeksi Emerg [Internet]. 2021; Available from: https://infeksiemerging. kemkes.go.id/ dashboard/covid-19.
Zhang B, Zhou X, Qiu Y, Song Y, Feng F, Feng J, et al. Clinical characteristics of 82 cases of death from COVID-19. PLoS One [Internet]. 2020;15(7 July):1–13. Available from: http://dx.doi.org/ 10.1371/journal.pone.0235458
Cheng L, Li H, Li L, Liu C, Yan S, Chen H, et al. Ferritin in the coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis. J Clin Lab Anal. 2020;34(10).
Iwasaki A, Yang Y. The potential danger of suboptimal antibody responses in COVID-19. Nat Rev Immunol [Internet]. 2020;20(6) :339–41. Available from: http:// dx.doi.org/10.1038/s41577-020-0321-6
Sabaka P, KoÅ¡Äálová A, Straka I, Hodosy J, Lipták R, Kmotorková B, et al. Role of interleukin 6 as a predictive factor for a severe course of Covid-19: retrospective data analysis of patients from a long-term care facility during Covid-19 outbreak. BMC Infect Dis. 2021;21(1):4–11.
Wang K, Wang X, Du J, Liu C, Jiang Y, Zhang H, et al. Relationship between changes in the course of COVID-19 and ratio of neutrophils-to-lymphocytes and related parameters in patients with severe versus mild/moderate disease. Epidemiol Infect. 2021;1–12.
Riandy MD, Purba BA, Puspita Y, Zainal R, Siswo L. Hubungan Rasio Neutrofil Limfosit dengan Mortalitas ≤28 hari di General Intensive Care Unit RSUP Dr. Mohammad Hoesin Palembang. J Anestesi Perioper [Internet]. 2019;7(3).
Lee JS, Kim NY, Na SH, Youn YH, Shin CS. Reference values of neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, platelet-lymphocyte ratio, and mean platelet volume in healthy adults in South Korea. Medicine (Baltimore). 2018 Jun;97(26):e11138.
Yang A-P, Liu J-P, Tao W-Q, Li H-M. The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients. Int Immunopharmacol [Internet]. 2020/04/13. 2020 Jul;84:106504. Available from: https://pubmed. ncbi.nlm.nih.gov/32304994
Lattanzi S, Brigo F, Trinka E, Cagnetti C, Di Napoli M, Silvestrini M. Neutrophil-to-Lymphocyte Ratio in Acute Cerebral Hemorrhage: a System Review. Transl Stroke Res. 2019 Apr;10(2):137–45.
Chen ZY, Raghav K, Lieu CH, Jiang ZQ, Eng C, Vauthey JN, et al. Cytokine profile and prognostic significance of high neutrophil-lymphocyte ratio in colorectal cancer. Br J Cancer [Internet]. 2015;112(6):1088–97. Available from: http://dx.doi.org/10.1038/ bjc.2015.61