Pengaruh Suplementasi Ekstrak Kulit Manggis Terhadap Kadar IL-8 dan Limfosit Pada Pasien COVID-19 dengan Cedera Hati Akut
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Latar belakang: Hati merupakan organ utama detoksifikasi dan metabolisme tubuh sehingga penting dalam pengobatan COVID-19. Salah satu pengobatan tradisional yang memiliki sifat hepatoprotektif adalah kulit manggis (Garcinia mangostana L.). Tujuan:Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak kulit manggis terhadap kadar IL-8 dan limfosit pada pasien COVID-19. Metode: Penelitian eksperimental ini dilakukan pada pasien positif COVID-19 di RS. Dr. Moewardi Surakarta. Sebanyak 40 pasien COVID-19 dibagi menjadi 2 kelompok: kelompok kontrol (tanpa terapi adjuvant) dan kelompok perlakuan (dengan suplementasi dry powder kapsul ekstrak kulit manggis dosis 3x1200 mg. Setelah 14 hari, pasien diperiksa kadar sitokin proinflamasi (IL-8) dan limfositnya. Data dianalisis menggunakan program SPSS 25.0 dan hasil dianggap bermakna bila nilai p <0,05. Hasil: Penurunan (selisih post-pre) kadar IL-8 kelompok kontrol (76.4 +234.6, 45.3%) lebih rendah secara bermakna daripada kelompok perlakuan (155.2+408.5, 54.3%) dengan p=0.048. Sedangkan peningkatan (selisih pre-post) kadar limfosit kelompok kontrol (2.2± 4.7, 13.9%) lebih rendah secara bermakna dari kelompok perlakuan (8.1±5.8, 50.9%) dengan p=0.001. Kesimpulan: pemberian ekstrak kulit manggis efektif menurunkan kadar IL-8 dan meningkatkan kadar limfosit pada pasien COVID-19 dengan cedera hati akut. Pemberian suplementasi dry kapsul ekstrak kulit manggis dapat menurunkan kadar IL-8 dan meningkatkan kadar limfosit secara bermakna pada pasien COVID-19 dengan cedera hati akut.
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Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(12):1708–20.
Nardo AD, Schneeweiss-Gleixner M, Bakail M, Dixon ED, Lax SF, Trauner M. Pathophysiological mechanisms of liver injury in COVID-19. Liver International. 2021 Jan 1;41(1):20–32.
Effenberger M, Grander C, Grabherr F, Griesmacher A, Ploner T, Hartig F, et al. Systemic inflammation as fuel for acute liver injury in COVID-19. Digestive and Liver Disease. 2021 Feb 1;53(2):158–65.
Bernhard S, Hug S, Stratmann AEP, Erber M, Vidoni L, Knapp CL, et al. Interleukin 8 elicits rapid physiological changes in neutrophils that are altered by inflammatory conditions. J Innate Immun. 2021 Sep 1;13(4):225–41.
Anirvan P, Narain S, Hajizadeh N, Aloor FZ, Singh SP, Satapathy SK. Cytokine-induced liver injury in coronavirus disease-2019 (COVID-19): untangling the knots. Vol. 33, European Journal of Gastroenterology and Hepatology. Lippincott Williams and Wilkins; 2021. p. E42–9.
Ardiani R. Karakterisasi Simplisia Dan Skrining Fitokimia Serta Uji Antimutagenik Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L.) Pada Mencit Jantan Menggunakan Metode Mikronukleus. repositori.usu.ac.id. 2021;1–40.
7Dang TH, Kim JY, Kim HJ, Kim BJ, Kim WK, Nam JH. Alpha-Mangostin: A Potent Inhibitor of TRPV3 and Pro-Inflammatory Cytokine Secretion in Keratinocytes. Int J Mol Sci. 2023 Aug 1;24(16).
Yiemwattana I, Kaomongkolgit R. Alpha-mangostin suppresses IL-6 and IL-8 expression in P. gingivalis LPS-stimulated human gingival fibroblasts. Odontology. 2015 Sep 23;103(3):348–55.
Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. Vol. 395, The Lancet. Lancet Publishing Group; 2020. p. 1033–4.
Gao Y, Li T, Han M, Li X, Wu D, Xu Y, et al. Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. J Med Virol. 2020 Jul 1;92(7): 791–6.
Ma A, Zhang L, Ye X, Chen J, Yu J, Zhuang L, et al. High Levels of Circulating IL-8 and Soluble IL-2R Are Associated With Prolonged Illness in Patients With Severe COVID-19. Front Immunol. 2021 Jan 29;12.
Hu YH, Han J, Wang L, Shi C, Li Y, Olatunji OJ, et al. α-Mangostin Alleviated Inflammation in Rats With Adjuvant-Induced Arthritis by Disrupting Adipocytes-Mediated Metabolism-Immune Feedback. Front Pharmacol. 2021 Jul 7;12.
Fu T, Li H, Zhao Y, Cai E, Zhu H, Li P, et al. Hepatoprotective effect of α-mangostin against lipopolysaccharide/D-galactosamine- induced acute liver failure in mice. Biomedicine and Pharmacotherapy. 2018 Oct 1;106:896–901.
Prasad AS. Zinc: An antioxidant and anti-inflammatory agent: Role of zinc in degenerative disorders of aging. Vol. 28, Journal of Trace Elements in Medicine and Biology. Elsevier GmbH; 2014. p. 364–71.
Tavakolpour S, Rakhshandehroo T, Wei EX, Rashidian M. Lymphopenia during the COVID-19 infection: What it shows and what can be learned. Vol. 225, Immunology Letters. Elsevier B.V.; 2020. p. 31–2.
Ni M, Tian FB, Xiang DD, Yu B. Characteristics of inflammatory factors and lymphocyte subsets in patients with severe COVID-19. J Med Virol. 2020 Nov 1;92(11):2600–6.
Meniailo ME, Malashchenko VV, Shmarov VA, Gazatova ND, Melashchenko OB, Goncharov AG, et al. Direct effects of interleukin-8 on growth and functional activity of T lymphocytes. Int Immunopharmacol. 2017 Sep 1;50:178–85.
Supranto, J. 2007. Teknik sampling : untuk survei dan eksperimen / J. Supranto. Jakarta : Rineka Cipta, 2007.
Setiawan, A.A., Budiman, J. and Prasetyo, A. (2023) ‘Anti-Inflammatory Potency of Mangosteen (Garcinia mangostana L.): A Systematic Review’, Open Access Macedonian Journal of Medical Sciences, 11(F), pp. 58–66. Available at: https://doi.org/10.3889/oamjms.2023.8746.
Jang, H., Kwon, O.,Oh, S.,Lee, H.,Ahn, K.,Chin, Y. 2012. Mangosteen Xanthones Mitigate Ovalbumin-Induced Airway Inflammation in A Mouse Model Of Asthma. Food And Chemical Toxicology. 50(11), Pp. 4042–4050. Doi: 10.1016/J. Fct.2012.08.037.
Tjahjani, S., Widowati, W., Khiong, K., Suhendra, A. And Tjokropranoto, R. 2014. Antioxidant Properties of Garcinia Mangostana L (Mangosteen) Rind. Procedia Chemistry. 13(2009), Pp. 198–203. Doi:10.1016/J.Proche.2014.12.027.
Widowati, W. et al. (2015). High Performance Liquid Chromatography (HPLC) Analysis, Antioxidant, Antiaggregation of Mangosteen Peel Extract (Garcinia mangostana L.), International Journal of Bioscience, Biochemistry and Bioinformatics, 4(6), pp. 458–466. doi: 10.17706/ijbbb.2014.4.6.458-466
Pedraza-chaverri, J. et al. (2008). Medicinal properties of mangosteen (Garcinia mangostana)‘, Food and Chemical Toxicology. Elsevier Ltd, 46(10), pp. 3227–3239. doi: 10.1016/j.fct.2008.07.024.
Sukatta, U., Takenaka, M., Ono, H., Okadome, H., Sotome, I., Nanayama, K., Thanapase, W., Isobe, S. (2013). Distribution Of Major Xanthones in The Pericarp, Aril, And Yellow Gum of Mangosteen (Garcinia Mangostana Linn.) Fruit And Their Contribution to Antioxidative Activity. Bioscience, Biotechnology, And Biochemistry; 77(5), Pp. 984–987. Doi: 10.1271/Bbb.120931.
Permana, AW, Siti Mariana Widayanti, Sulusi Prabawati, dan Dondy A Setyabudi. (2012) Sifat Antioksidan Bubuk Kulit Buah Manggis (Garcinia Mangostana L.) Instan Dan Aplikasinya Untuk Minuman Fungsional Berkarbonasi. J. Pascapanen 9(2) 2012: 88 - 9.
Zhang J, Bai C. Elevated serum interleukin-8 level as a preferable biomarker for identifying uncontrolled asthma and glucocorticosteroid responsiveness. Tanaffos. 2017;16(4):260–9.
Milcic TL. The complete blood count. Neonatal Netw. 2010;29(2):109–15.
Yaylaci S, Dheir H, Şenocak D, Genc AB, Kocayigit H, Çekiç D, et al. The effects of favipiravir on hematological parameters of covıd-19 patients. Rev Assoc Med Bras. 2020;66(Suppl 2):65–70.
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